1791Evaluating Cryptococcal Antigen Lateral Flow Assay by Fingerstick Whole Blood in HIV-Infected Persons with Meningitis
نویسندگان
چکیده
1791. Evaluating Cryptococcal Antigen Lateral Flow Assay by Fingerstick Whole Blood in HIV-Infected Persons with Meningitis Darlisha Williams, MPH; Kiiza Tadeo,; Sruti Velamakkani,; Reuben Kiggundu,; David Meya, MMed; Joshua Rhein, MD; David Boulware, MD, MPH; Center for Infectious Diseases & Microbiology Translational Research, University of Minnesota, Minneapolis, MN; Infectious Disease Institute, Makerere University, Kampala, Uganda; Infectious Disease and International Medicine, University of Minnesota, Minneapolis, MN
منابع مشابه
Evaluation of Fingerstick Cryptococcal Antigen Lateral Flow Assay in HIV-Infected Persons: A Diagnostic Accuracy Study
BACKGROUND Cryptococcus neoformans is the most common cause of adult meningitis in sub-Saharan Africa. The cryptococcal antigen (CRAG) lateral flow assay (LFA) has simplified diagnosis as a point-of-care test approved for serum or cerebrospinal fluid (CSF). We evaluated the accuracy of the CRAG LFA using fingerstick whole blood compared with serum/plasma and CSF for diagnosing meningitis. MET...
متن کاملPerformance of cryptococcal antigen lateral flow assay in serum, cerebrospinal fluid, whole blood, and urine in HIV-infected patients with culture-proven cryptococcal meningitis admitted at a Brazilian referral center
Cryptococcal meningitis is the most common cause of opportunistic meningitis in HIV-infected patients in Brazil and causes unacceptable high mortality rates. In this study, HIV-infected patients with a first episode of culture-proven cryptococcal meningitis in cerebrospinal fluid (CSF) were prospectively included in order to evaluate sensitivity of cryptococcal antigen (CrAg) lateral flow assay...
متن کاملPerformance of Cryptococcal Antigen Lateral Flow Assay Using Saliva in Ugandans with CD4 <100
BACKGROUND Cryptococcal meningitis can best be diagnosed by cerebrospinal fluid India ink microscopy, cryptococcal antigen detection, or culture. These require invasive lumbar punctures. The utility of cryptococcal antigen detection in saliva is unknown. We evaluated the diagnostic performance of the point-of-care cryptococcal antigen lateral flow assay (CrAg LFA) in saliva. METHODS We screen...
متن کاملLateral Flow Assay for Cryptococcal Antigen: an Important Advance to Improve the Continuum of Hiv Care and Reduce Cryptococcal Meningitis-related Mortality
AIDS-related cryptococcal meningitis continues to cause a substantial burden of death in low and middle income countries. The diagnostic use for detection of cryptococcal capsular polysaccharide antigen (CrAg) in serum and cerebrospinal fluid by latex agglutination test (CrAg-latex) or enzyme-linked immunoassay (EIA) has been available for over decades. Better diagnostics in asymptomatic and sy...
متن کاملDiagnosis of Cryptococcosis and Prevention of Cryptococcal Meningitis Using a Novel Point-of-Care Lateral Flow Assay
Despite access to antiretroviral therapy, mortality from cryptococcal meningitis (CM) is high among persons with advanced HIV infection in sub-Saharan Africa. Cryptococcal antigen (CrAg) is present several weeks to months before the onset of symptoms of meningitis and can be screened to prevent life threatening meningitis. Recently, the World Health Organisation recommended that a new rapid CrA...
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2014